Oklahoma’s Frontier Drugstore Museum

Oklahoma Frontier Drugstore Museum, Oklahoma© 2009 Nell ThalasinosMuseum director Mark Ekiss plays soda jerk for a day at the authentic old-time soda fountain.

214 W. Oklahoma Ave., Guthrie, Oklahoma

Step straight into the Oklahoma Territory’s earliest days at the Oklahoma Frontier Drugstore Museum, housed in the 1890 Gaffney Building, the site of Oklahoma’s first drugstore.

Patent medicines and period advertisements share space with such curiosities as a blue-and-white ceramic leech jar—a reminder that physicians once used leeches to rid the body of maladies. A period soda fountain in the museum serves up old-fashioned sundaes and phosphates, and an inviting apothecary garden on the building’s west side scents the air with wild thyme, echinacea, and other medicinal herbs.

Explore the streets of Guthrie, whose 400-block downtown district is among the largest urban areas listed in the National Register of Historic Places.

Open Tues. – Sat. Admission charged.


(405) 282-1895

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