Danger! How Grapefruit and Medications Don’t Mix

43 different drugs can interact dangerously with grapefruit; here's what you need to know.

Danger! How Grapefruit and Medications Don’t MixHalley Resources

It’s been known for a while that grapefruit juice can interact with certain medications and dangerously increase their potency, due to chemicals called furanocoumarins (also present in limes and Seville oranges).

New research has found that the number of drugs that interact badly with grapefruit juice—­including some common blood-pressure and cholesterol-lowering medications—has more than doubled since 2008 thanks to new drug formulations.“Taking one tablet of certain medications with a glass of grapefruit juice can be like taking five tablets with water,” says lead researcher David Bailey, PhD, a clinical pharmacologist at the Lawson Health Research Institute in London, Ontario.

A single grapefruit or glass of juice—even if consumed hours before or after a drug is taken—is enough to cause a reaction. Check with your doctor to see if any medications you take are on the new list.

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