The Best Wrinkle Fighters

Reduce the Appearance of Wrinkles Know the topical ingredients clinically shown to help reduce the appearance of wrinkles and fine lines.

The skin-care aisle is packed with antiaging products and claims. Here are the topical ingredients clinically shown to help diminish the fine lines and wrinkles that appear when collagen fibers break down.


  • 1.

    Vitamin A

    Often listed as retinol, it penetrates skin to increase collagen production, eventually smoothing lines, says Flor A. Mayoral, MD, a South Miami dermatologist.

  • 2.

    Vitamin C

    It can stimulate collagen to help build up your skin and smooth and fade lines. It works best when you apply it at night, says Arthur W. Perry, MD, a clinical associate professor of plastic surgery at Robert Wood Johnson Medical School.

  • 3.

    Vitamin E

    Look on the label for DL-alpha-tocopherol; it blocks the cancer-causing effects of UV light and slows the production of wrinkles. And E enhances the efficacy of sunscreen, decreasing redness and swelling after sun exposure.

  • 4.

    Alpha hydroxy acid (AHA)

    Used as an exfoliant, it’s also listed as glycolic acid. By peeling off the top layer of dead skin, it gives you a more youthful appearance.

  • 5.

    Vitamin B3 (niacin)

    It helps shield skin from toxins and decreases brown blotches. Bonus: It helps ease the irritation that can be a side effect of vitamin A creams.

Want to stay smart and healthy?

Get our weekly Health Reads newsletter

how we use your e-mail

Some people like to travel by train because 
it combines the slowness of a car with the cramped public exposure of 
an airplane.

Dennis Miller

I think my pilot was a little inexperienced. We were sitting on the runway, and he said, “OK, folks, we’re gonna be taking off in a just few—whoa! Here we go.”

Kevin Nealon

“I can’t wait until your vacation is over.” 
—Everyone following you on Instagram


A man knocked on my door and asked for a donation toward the local swimming pool. So I gave him a glass of water.

Comedian Greg Davies

Funny Jokes

Just found the worst page in the entire dictionary. What I saw was disgraceful, disgusting, dishonest, and disingenuous.


Funny Jokes

Client: We need you to log in to the YouTube and make all our company videos viral.


Funny Jokes

My cat just walked up to the paper shredder and said, “Teach me 
everything you know.”


Funny Jokes

“Just because you can’t dance doesn’t mean you shouldn’t dance.” 

@yoyoha (Josh Hara)

Funny Jokes

My parents didn’t want to move to Florida, but they turned 60 and that’s the law.

—Jerry Seinfeld

Funny Jokes

Q: What do you call an Amish guy with his hand in a horse’s mouth?

A: A mechanic.