Dr. Miracle

George Griffin's fellow physicians thought he was a goner. But they didn't figure on one thing.

His Life's Work

For nearly three decades I've practiced medicine, treating and studying cancer, blood diseases, HIV and hepatitis C. During much of that time, I did not consider the impact of hope on my patients' illnesses. In fact, the fairy-tale claims about hope caused me to flee from the subject. Then something happened that changed my attitude forever. On a summer evening in 1987, I went to the hospital to visit an ill colleague. George Griffin -- Harvard professor, revered and beloved chairman of our department of pathology -- had been diagnosed with stomach cancer, the worst type that one can have. In cases like his, only two to three percent of patients live six months. At nine months, survival is less than one percent. The bitter irony was that stomach cancer was the disease that George had made his life's work. No one knew more about the malignancy and its dire prognosis than he.

Nonetheless, George had insisted on receiving aggressive treatment combining high doses of chemotherapy with intensive radiation, despite the absence of evidence that such toxic therapy could change the fatal outcome of a cancer as advanced as his. It was clear his treatment risked hastening his demise, or at least robbing him of the last tranquil days at home with his family and friends. I would not ordinarily treat a patient with George's prognosis this way. But I was not consulting on his case.

I entered George's room. The sheets were drawn to his neck. His eyes were closed and sunken, his skin ashen, his lips blackened from dried blood in deep ulcers. For a moment, I wondered if he had died. Then he slowly turned his head and noticed me. With tears in his eyes, George struggled to speak.

"Don't talk," I said. His eyes closed in assent. George had suffered a severe side effect of the treatment; essentially the delicate lining tissue from his lips to his rectum was scorched, ulcerated and bleeding. I spent a few minutes with him, and as I departed, I thought how I would usually offer a patient words of encouragement, saying how vital it was to keep fighting against the cancer. I knew that in some cases if the patient could endure the harsh treatment, the cancer might be eradicated. But in George's case, such words seemed hollow. So instead I left with platitudes, saying how much everyone missed him, how we all were thinking of him and hoping that soon he might find some relief.

For days I could not get George out of my mind. I sought to replace the awful images from my last visit with memories of George Griffin in full health. Sixty-one years old, a wiry man of middle height, with thinning gray hair and sharp features, he had ventured into the most remote corners of Asia studying the epidemiology of stomach cancer. George was particularly interested in Korea and in rural China, where the incidence of the disease was high. This interest deepened after his first wife died of colon cancer and George had married Eunha, a Korean pathologist.

Despite Eunha's pleas for him to rest, George came back to work two or three hours a day once the chemical burn from the high doses of chemotherapy and radiation had subsided. He had lost nearly 30 pounds.

Then one day news moved like a shock of electricity through the clinical staff: George was scheduled for surgery. "Why not just put a gun to his head?" one colleague said bitterly.

A CAT scan did show some decrease in the size of the mass and surrounding lymph nodes, but such changes in response to radiation and chemotherapy are almost always transient, and do not alter the ultimate outcome. Moreover, a surgeon's scalpel could not remove the multitude of cancer cells that already had entered George's blood vessels and were deposited throughout his abdomen like buckshot. Within weeks, they would regrow and spread again. Ultimately major surgery only risked stealing more days away from the few that remained for George.

All names have been changed to protect privacy.

• • Inspiring Stories
• • Survival Stories
• • Unbelievable
• • Action Stories
• • Natural Disasters

• The Brooke Ellison Story
• A screech of brakes, a small body flying through the air -- and 11-year-old Brooke Ellison couldn't move or even breathe on her own. But the story was just beginning.
• 
• Invincible
• Badly burned in the World Trade Center, Lauren Manning had the will to live.
• 
• The Dog That Heals
• With a wet nose and a wagging tail, Ella brings comfort to those in need.
• 

• Be Inspired
• 10 Celebrities Who Give Back
• 7 Amazing Stories, $700,000 to Charity
• Virginia Cervasio: Making It Matter
• PLUS:
• Quiz: What's Your Celebrity Cause IQ?