16 Anti-Aging Creams Dermatologists Trust the Most
Don’t just pick a random product off the shelves and pray that it works—these are the anti-aging creams that actually follow through on their promises.
Isdin Isdinceutics Melatonik
This three-in-one night serum promises to boost your skin’s defenses, repair damage, and fight wrinkles. Its combination of vitamin C, melatonin, and bakuchiol is a gentle alternative to anyone who finds retinoids too strong, says Melissa Kanchanapoomi Levin, MD, New York City dermatologist and founder of Entiere Dermatology. “Bakuchiol is derived from a plant native to India, which has [been] shown to induce collagen production, improve pigmentation, and improve skin elasticity without causing irritation or dryness,” she says. You might think of melatonin as a sleep inducer, but for your skin, it protects against environmental damage from the sun and air pollution. Don’t miss these other 14 anti-aging breakthroughs you should know about.
SkinMedica TNS Essential Serum
This formula is “one of the best on the market,” says Jeanine Downie, MD, a board-certified dermatologist with Image Dermatology. It uses powerful proteins called growth factors to help the skin maintain its youthful glow, even as you start losing the collagen that keeps your skin plump. “After age 20, your collagen starts wilting,” says Dr. Downie. “Growth factor keeps your skin from sagging, improves the texture of the skin, and reduces fine lines and wrinkles.”
SkinMedica TNS Recovery Complex
An ounce of prevention is worth a pound of cure, as they say, and it’s never too early to start an anti-aging cream. While SkinMedica TNS Essential Serum is great for aging skin, the Recovery Complex is a great option for the under-45 crowd, says Dr. Downie. Like in its sister product, the patented Tissue Nutrient Solution (TNS) rejuvenates the skin to fight wrinkles, plus even out the tone and texture. No matter what your age, you’ll want to know the best anti-aging products for every decade of your life.
Neutrogena Rapid Repair Regenerating Cream
Neutrogena touts itself as dermatologist-recommended for good reason. “They actually test the skin and have clinical trials to make sure [products] are working,” says board-certified dermatologist Edidiong Kaminska, MD, co-founder of Kaminscy Medical and Surgical Consulting Incorporated. “As physicians, we like data; we like evidence-based medicine.” This anti-aging cream uses retinol and hyaluronic acid to smooth out wrinkles and make the skin look plump and youthful.
Dealing with wrinkles and acne? The worst. That’s where Differin Gel steps in—Dr. Levin calls it the “gold standard” for almost any kind of acne. “Topical retinoids such as Differin Gel are a derivative of Vitamin A and help to normalize skin cell turnover, which will prevent clogged pores and ultimately, treat and prevent acne,” she says. “Retinoids also help improve skin discoloration, texture and tone therefore, it will restore the skin from prior breakouts.”
Skinbetter Science AlphaRet Overnight Cream
To get the benefits of retinoids without all the dryness and irritation, give Skinbetter Science AlphaRet Overnight Cream a try. Its combination of ingredients—including retinoids, antioxidants, and lactic acid—not only fights fine lines and evens out skin tone and texture, but also delivers moisture to keep skin feeling soft. It tends to be better tolerated than similar products, but still delivers the same age-erasing power as a prescription-strength Tretinoin, says Dr. Levin.
Skinbetter Science Alto Defense Serum
“Skinbetter Science Alto is an antioxidant powerhouse that protects from and corrects premature signs of aging caused by the sun, environment, and tech devices,” says Marnie B. Nussbaum, MD, a New York City-based dermatologist. Powerhouse is right—this formula contains a whopping 19 antioxidant ingredients to shield against free radicals, those pesky unstable atoms that can damage the body’s cells and contribute to aging. Meanwhile, you’ll want to load up on these 13 foods directly tied to younger-looking skin.
GlyDerm Face Lotion 5
“Glyderm Face Lotion 5 is a gentle nighttime exfoliating lotion for normal to oily skin that helps to decongest skin while blurring dark spots and enhancing hydration,” says Dr. Nussbaum. Glycolic acid is a key ingredient, exfoliating to shed dead skin away while boosting collagen, a protein that keeps your skin plump and youthful.
GlyDerm Cream 5
Skin more on the dry side? GlyDerm Cream 5 could be one of the anti-aging creams for you. It uses mineral oil and petrolatum to soften the skin and lock in moisture—in addition to its anti-aging properties, of course. “The GlyDerm Cream 5 helps to diminish fine lines and wrinkles and the unwanted appearance of irregularities to reveal a brighter, younger-looking complexion,” says Dr. Nussbaum.
RoC Retinol Correxion Deep Wrinkle Anti-Aging Retinol Night Cream
The retinol you’ll find in OTC anti-aging creams generally won’t have the same level of wrinkle-fighting power retinoids a doctor can prescribe, but that doesn’t mean they won’t give you results. “RoC makes really good retinoids,” says Dr. Kaminska. “They’re not equivalent to a prescription, but you get the results quickly.” According to the company’s clinical trials, you should see results within 12 weeks. Best of all? At under $15, this anti-age cream won’t break the bank. Check out the other best anti-aging products at every price point.