14 Simple Ways to Make Your Vitamins More Effective

If you're going to make the effort to take vitamins, minerals, and other supplements daily to improve your health and nutrition, you owe it to yourself to use these simple strategies to make them as effective as possible.

Take them with food

cookingUndrey/shutterstockThere are some secrets vitamin manufacturers don't want you to know, but it's no secret that you should always take your vitamins at mealtimes. "When you consume foods, it initiates a cascade of digestive processes that help absorb the nutrients from food, and this will also optimize the absorption of the vitamins and minerals," explains Douglas "Duffy" MacKay, ND, senior vice president and scientific and regulatory affairs for the Council for Responsible Nutrition in Washington, DC. There's another reason too. "Taking vitamins and minerals with food helps to prevent nausea which some people may experience from supplements." Of course, there are exceptions to every rule—and in this case, it's iron. Take it in the AM on an empty stomach for better absorption, advises Los Angeles sleep expert Michael J. Breus, PhD., author of several books on sleep and optimum scheduling, including The Power of When.

Learn how they work with your other meds

medicationDavidSmart/shutterstockOf all the vitamin mistakes you may not realize you're making, perhaps the most problematic is ignoring other pills you may be taking, because as MacKay warns, vitamins and minerals can interact with prescription and over-the-counter meds. In some cases, this will make one or the other less effective and in other cases, it could amplify their effects and put you at risk for an overdose. For example, calcium may interfere with the absorption of a commonly prescribed thyroid medication, and many women take both. "They compete for absorption in the blood stream and should be taken a few hours apart," MacKay says. In some cases, supplements may help drugs work better, he says. Cholesterol-lowering statins may cause fewer muscle and joint aches if taken with supplements of coenzyme Q10 (CoQ10). CoQ10 plays a role in muscle cell energy production, which is why supplementing may reduce these statin side effects. CoQ10 has other benefits as well. Ask your doctor or pharmacist for guidance if you take medication and vitamins or minerals. And while you are at it, here are other super-important questions to ask before taking prescription meds.

Get schooled on fat- versus water-soluble vitamins

vitaminsArtTim/shutterstockKnowing the difference between fat and water solubles will help you get the most out of your vitamins. Fat-soluble vitamins—namely A, D, E, and K—are stored in the body, where they can accumulate and in some cases, cause harm. By contrast, water-soluble vitamins such as the B vitamins—folate, thiamine, riboflavin, niacin, pantothenic acid, biotin, vitamin B6, and vitamin B12—and vitamin C, are excreted in the urine so they can't build up in the body like their fat-soluble counterparts, explains Chris D'Adamo, PhD, Assistant Professor at the University of Maryland School of Medicine and Director of Research at the Center for Integrative Medicine in Baltimore. "This is the reason our urine is brightly colored after we take certain water-soluble vitamins." Here's what your urine color says about your health.

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Eat fat with fat-soluble vitamins

yogurtAfricaStudio/shutterstockFat-soluble vitamins tend to be better absorbed when eaten with fat. "And the morning would make sense if you drink milk, eat yogurt, or put avocado in your AM smoothie," adds Dr. Breus. How much of a boost are we really talking about? It varies by vitamin, but one study published in a 2015 issue of the Journal of the Academy of Nutrition and Dietetics found that men who took vitamin D with a high-fat breakfast had 32 percent greater absorption of the vitamin than those who ate a fat-free morning meal. These are the signs you could be low in vitamin D.

Consider both form and function

vitaminsMIA Studio/shutterstockMagnesium is one of the most underrated minerals, and many of us don't get enough of it. (Here are some signs that you may not be getting enough magnesium.) The problem may be how you take your magnesium supplements, as certain minerals—including magnesium—may be easier to digest and absorb and less likely to degrade when taken in liquid form. "If a vitamin is taken as tablet or capsule, your body has to break it up to dissolve it, but when consumed as a liquid, you can bypass that step," MacKay says. That said, most forms of vitamins—even gummies—are created equally. "The choices are more about preferences, as some people can't swallow these giant pills," he says. Your best bet is to choose whichever form you are most comfortable with and make sure it contains all of the vitamins and minerals that you need.

Know when to pair

vitaminsStephenGibson/shutterstockSome vitamins and minerals are better together, D'Adamo says. This includes vitamin D, Vitamin K, and calcium. Vitamins D and K help the body and bones absorb calcium, so taking them together is one of many simple ways to boost your bones. Other winning combos include iron and vitamin C, as Vitamin C helps the body release a higher percentage of iron. "In a study we did, taking iron with vitamin C reduced side effects seen with iron such as constipation and nausea and boosted absorption," says D'Adamo. A lot of times vitamins that go better together are packaged together, he says, but it pays to look for those combos.

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Know when to split

vitaminsMarieCField/shutterstockSome vitamins and minerals are best when taken separately. "Zinc and copper compete with one another, as do iron and zinc when they are out of ratio, but multivitamins keep it balanced," D'Adamo says. Calcium also inhibits iron, which means they should be separated, Dr. Breus adds. "The good news is that calcium can have a generally calming effect on many people and is unlikely to upset your stomach, therefore you should take iron in the AM, and calcium in the PM."

Splitting pills can also make sense with some water-soluble vitamins, Dr. Breus says. "If a vitamin is water soluble, then you will urinate much of it out on your next bathroom trip, so some will need to be taken more than one time per day." This is often good call when it comes to vitamin C, he says.

Skip the grapefruit juice

 grapefruitbalbaz/shutterstockDanger! Grapefruit and medications don't mix. Grapefruit juice not only increases the potency of some substances in the body, but it also interferes with the absorption of other supplements such as St. John's Wort, which is widely used to treat mild to moderate depression. It's worth checking out whether any of your vitamins and minerals interact with grapefruit juice.

Get screened

doctorspreewaldDOTpictureDOTde/shutterstockOne of the best ways to see if you're getting enough of some important vitamins and nutrients is to get a blood test. It won't give you a complete picture, but it can accurately detect levels of vitamin D as well as iron in your blood and let you know whether you need more or less. This is key, as too-low levels of lifesaving vitamin D have been associated with osteoporosis, diabetes, hypertension, and cancer. These silent signs of nutrient deficiency may also give you a clue as to what's missing. It's a good idea to consider your family health history, so you can look into vitamins that might help prevent certain diseases that may run in your family such as folate malabsorbtion disorder, which interferes with the body's ability to absorb certain B vitamins or folates from food, MacKay says. Here are the things your mother's health can tell you about you.  

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Look into digestive enzymes or probiotics

probioticuduhunt/shutterstockDo you need probiotics? You might. Probiotics are pretty popular these days, and their use is on the rise, according to a study in the Journal of the American Medical Association. "Probiotics help change the balance of good and bad bacteria that can get thrown off in certain health conditions," D'Adamo says. And they may also make our vitamins more effective. "They do help us digest and assimilate nutrients better," he says. Same goes for digestive enzymes. "There haven't been a lot of studies, but we do know that plant-based digestive enzymes tend to survive stomach acid better, so they can help with absorption of certain nutrients that may normally get destroyed by the acid," says D'Adamo. Essentially, plant-based digestive enzymes—such as bromelain from pineapple—encourage the chemical breakdown of food into smaller more absorbable pieces. People with food intolerances who can't break down certain foods and nutrients (like lactose in dairy), find them particularly helpful. These are the signs of lactose intolerance you might overlook.

Know how and where to store your stash

foodPattyChan/shutterWhere and how you store vitamins and supplements can also affect their potency. "Probiotics should be shipped and stored cold in the refrigerator," D'Adamo says. They contain live cultures, so if they're not shipped cold, they'll be dead on arrival as a result. Omega-3 fatty fish oil, another best-selling supplement, should be kept in a cold, dark spot, as the pills are at risk for degradation from heat, light, and oxygen. (If you tend to experience smelly fish burps from these supplements, store them in the freezer so they bypass the stomach entirely, D'Adamo advises.)

Go natural

vitaminallstars/shutterstockVitamin E is loaded with health benefits, and natural forms are twice as bioavailable as synthetic ones, D'Adamo says, which means your body can use more of the good stuff the capsules contain. How can you tell if you are taking natural C? "It would have a D on the label, while DL means synthetic," he says. Vitamin E is the generic name for tocopherol, which is one type of the vitamin. "There are eight forms of Vitamin E, and your best bet is to pick 'mixed tocopherols' with a D on the label, as you get a better balance of the different types out there that are also more bioavailable," he says.

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Time them right

vitaminJinningLi/shutterstockThere are different road rules for different vitamins and minerals when it comes to the best time to take them. "All B Vitamins should be taken in the morning, as they tend to give people energy," Dr. Breus says. While most vitamins are taken first thing in the AM, others should be reserved for evenings largely because, like these 16 foods that can help you sleep, some supplements may make you feel sleepy. This includes melatonin and valerian root. "Magnesium has a true calming effect, and in some cases it can make people feel downright sleepy, so it is best taken just before bed," adds Dr. Breus. Did you know that magnesium can help with depression?

Watch your caffeine intake

coffeeBillionPhotos/shutterstockCaffeine in your morning joe may interfere with the absorption of vitamins and minerals—and as a diuretic, it also makes us pee more, speeding the rate at which we excrete water-soluble vitamins. Caffeine may also leach calcium from the body and bones. Minimize these risks by consuming moderate amounts of caffeine and making sure you're getting enough calcium plus vitamin D. (Here's how to tell if you're drinking too much coffee, by the way.)

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