Where to start:
The sunniest spot in your yard is the best place to stake out your plot, because most vegetables need a minimum of 6 hours of sun daily. Because vegetables like lots of moisture, grow yours near a water source. Finally, vegetables always have the unwanted company of weeds, so monitor your plot weekly to pull up invaders as you watch your vegetables grow.
How your rows should run:
In temperate climates, make sure your vegetable rows run from east to west, so that all the plants receive maximum sunshine. In hot, arid climates, run the rows from north to south so that each plant will shade its neighbor on the warm south side.