15 Mysterious Disappearances That No One Can Explain

Lauren Cahn

By Lauren Cahn

Updated on Sep. 22, 2025

There's something uniquely disturbing about people vanishing into thin air. Here are over a dozen mysterious disappearances that have left experts scratching their heads.

Gone without a trace

Few things capture the imagination and strike fear like mysterious disappearances. From vanished explorers to everyday people who disappeared into thin air, these cases leave behind more questions than answers. Historians, law enforcement and even psychologists have studied them for centuries, yet the chilling reality remains: Some stories of human disappearance defy logic. These aren’t just tales for true-crime enthusiasts—they’re puzzles that touch on the deepest human fears of loss, uncertainty and the unknown.

When it comes to missing persons cases, experts point out that while many are eventually solved, others linger in history as eerie reminders of how fragile human presence can be. Some are tied to wars or natural dangers, while others appear to be outright unexplained vanishings. Despite advanced forensic tools and investigative breakthroughs, these mysteries remain unsolved, often leaving families without closure and fueling endless speculation.

From Virginia Dare at Roanoke to modern-day figures like Lauren Spierer, these unsolved disappearances span centuries and continents but share one unsettling trait: no definitive ending. Each case challenges our understanding of safety, identity and even history itself. Ready to step into the shadows? Let’s explore some of the most baffling vanishings that continue to stump investigators and fascinate the world.

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15 Mysterious Disappearances No One Can Explain
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The Roanoke Colony

John White, the governor of Roanoke Colony in Virginia, was there when the first English child—his granddaughter, Virginia Dare—was born in the Americas. Shortly after her birth on Aug. 18, 1587, White left Roanoke for England, intent on gathering supplies and garnering additional support. He’d never see Virginia or any of the colonists again.

By the time he returned, the entire colony had vanished—not just the people but every structure. To this day, historians consider it one of the most famous unexplained vanishings, with no clear evidence of what happened to Virginia or the rest of the Roanoke colonists.

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15 Mysterious Disappearances No One Can Explain
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Owen Parfitt

The disappearance of Owen Parfitt from his sister’s front porch in the English countryside may not be the most famous of all mysterious disappearances, but it’s certainly one of the more puzzling. In the summer of 1763, Parfitt, who was paralyzed and in his 60s, vanished while sitting outside. Farm workers across the road claimed they saw no one approach or leave. One moment he was there; the next he was gone. His story remains one of history’s strangest unsolved disappearances.

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Old letters
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Ambrose Bierce

American author Ambrose Bierce, whose writings partly inspired HBO’s True Detective, became the subject of his own mystery in 1913. At more than 70 years old, he told friends he was heading to Mexico to join Pancho Villa’s revolution. After a few letters from the frontlines, he was never seen or heard from again. Some believe he was killed in action, while others suspect suicide. Bierce’s fate remains one of the most baffling missing persons cases of the early 20th century and continues to be listed among the strangest unsolved mysteries of all time.

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vintage typewriter and books on the table with blank paper on wooden desk
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Barbara Newhall Follett

Barbara Newhall Follett created a fantasy language at age 8 and published her first novel at age 13, but her success came at a cost. By 25, she had fallen into depression. On Dec. 7, 1939, after an argument with her husband, she walked out of their home and never returned. Despite extensive searching, her body was never found. Her story still haunts the literary world today.

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Wooded Path in Michigan
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Paula Jean Welden

In December 1946, Bennington College sophomore Paula Jean Welden set out for a long walk and never came back. The authorities were stumped, and making the search even more complicated was the fact that Vermont didn’t have a state police at the time. After a local man bragged to his pals that he knew where her body was buried, police thought they had a break in the case … but he couldn’t lead them to a site and later said he was all talk.

Welden’s case is one of Vermont’s most enduring unsolved disappearances, and it remains a chilling entry in the so-called Bennington Triangle, a hot spot for mysterious disappearances.

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Old bus interior
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James Tetford

Not only did several people mysteriously disappear around Bennington, Vermont, but they did so in the 1940s. Three years after Paula Jean Welden went missing, James Tetford vanished in the same region. He was last seen dozing on a crowded bus, but when it arrived at Bennington, Tetford was gone, leaving behind all his belongings. His 1949 disappearance, combined with others in the area, helped fuel talk of the Bennington Triangle.

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Dark Sea Water Surface
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The MV Joyita

On Oct. 3, 1955, the merchant vessel MV Joyita left Samoa for the Tokelau Islands but never reached its destination. A month later, the ghost ship was found drifting far off course with no crew, passengers or cargo. Some blamed piracy. Others suspected a premature evacuation after the boat began taking on water. The disappearance of all 25 aboard remains one of maritime history’s most chilling unexplained vanishings.
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15 Mysterious Disappearances No One Can Explain
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Patty Blough, Renee Bruhl and Ann Miller

On July 2, 1966, three young women in bathing suits boarded a small motorboat at a Lake Michigan beach. None were ever seen again. Crime reporter Dick Wylie believed they were headed to a floating abortion clinic and that something went fatally wrong. He theorized the women were silenced to eliminate witnesses. To this day, the case stands as an unsettling unsolved disappearance.

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Bow of a wooden boat
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The Sarah Joe

In February 1979, five friends took a small boat called the Sarah Joe out from Maui into what became one of Hawaii’s worst storms. They never returned. A decade later, the boat turned up wrecked on the Marshall Islands—next to the grave of one of the missing men. How he got there and who buried him remain unanswered questions. The Sarah Joe mystery continues to confound experts in missing persons cases.

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Vintage journalist
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Tom Young and Keith Reinhard

In 1987, Tom Young vanished near Silver Plume, Colorado. A year later, his body was found with an apparent self-inflicted gunshot wound. Around the same time, journalist Keith Reinhard became fascinated with Young’s story and began writing a novel about it. In 1988, Reinhard went for a hike and never came back. The eerie parallels between the two men’s fates cement this case as one of the region’s strangest unsolved disappearances.

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Lost the keys on the grass
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Jodi Huisentruit

On June 27, 1995, Iowa news anchor Jodi Huisentruit was abducted from her apartment complex parking lot on her way to work. Authorities found signs of a struggle, including her shoes, earrings and car key scattered by her vehicle. Despite palm prints and a hair sample collected at the scene, no one could solve the crime, and her fate remains unknown. Jodi’s story is among the most chilling missing persons cases in journalism history.

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Keyboard dirty computer old laptop abc apple alphabet
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Ray Gricar

On April 15, 2005, Ray Gricar, a homicide prosecutor in Pennsylvania, told his girlfriend he was skipping work for a drive. The next day, his car was found abandoned. Months later, his laptop and hard drive were recovered—damaged beyond use. Despite years of searching, police found no further trace of him, and two decades later, Gricar’s mysterious disappearance remains unsolved.

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Bright open bar
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Brian Shaffer

On April 1, 2006, medical student Brian Shaffer was recorded on security cameras entering a Columbus, Ohio, bar with friends. Strangely, there’s no footage of him leaving. Some believe he slipped away intentionally; others think foul play was involved. Either way, Shaffer’s case has become one of the most baffling unexplained vanishings in modern times, ranking alongside urban legends that turned out to be true.

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hiking boots on the forest floor
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Barbara Bolick

On July 18, 2007, experienced hiker Barbara Bolick vanished in Montana’s Bitterroot Mountains while out with a family friend. He claimed she walked ahead on the trail and then disappeared without a sound. Despite searches, no trace of her has ever been found. Her story is a haunting example of how the wilderness can complicate missing persons cases.

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Night Road on dark forest.
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Lauren Spierer

On June 3, 2011, Indiana University student Lauren Spierer disappeared after a night of partying with friends. Despite possible leads over the years, investigators have found nothing conclusive about this mysterious disappearance. Still, her parents continue to push for answers and justice.

FAQs

What is a mysterious disappearance, exactly?

A mysterious disappearance occurs when a person or group vanishes without a clear explanation or evidence of what happened. These cases often remain unsolved for years, sometimes forever.

Why do so many missing persons cases remain unsolved?

According to investigators, factors like a lack of witnesses, limited technology at the time and remote locations make it difficult for police to solve many disappearances. In some cases, evidence is lost before authorities even begin their search.

What is the most famous unsolved disappearance?

Amelia Earhart’s 1937 disappearance is among the most famous, still capturing the public’s attention 88 years later. Other high-profile disappearances include those of the Roanoke Colony, author Ambrose Bierce and Teamster Jimmy Hoffa.

Can modern technology solve old disappearance cases?

Yes. Advances in DNA testing, satellite imaging and digital forensics have helped solve some cold cases. However, many older unsolved disappearances lack physical evidence, making them nearly impossible to resolve.

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Sources:

  • History.com:  “The Lost Colony of Roanoke”
  • The New York Times: “A Mysterious Disappearance”
  • Library of Congress: “Ambrose Bierce Papers”
  • Farksolia: “Biography”
  • Cold Case New England: “Paula Welden”
  • Vermonter: “The Fantastic Mysteries of Vermont’s Bennington Triangle”
  • Samoa Observer: “MV Joyita – the mystery of Samoa’s ghost ship”
  • NBC News: “What happened to three young sunbathers who disappeared at Indiana Dunes State Park 57 years ago?”
  • The Maui News: “40 years later, mystery still surrounds the Sarah Joe and its five Hana fishermen who didn’t return”
  • Colorado Bureau of Investigation: “Keith R Reinhard”
  • People: “Jodi Huisentruit Was Running Late to Work When She Disappeared in 1995”
  • WGAL: “What happened to Ray Gricar? 20 years later, still no answers about disappearance”
  • FBI: “Brian Randall Shaffer – Columbus, Ohio”
  • NBC Montana: “Missing Bitterroot woman still a mystery”
  • WTHR: “Tuesday marks 14 years since disappearance of IU student Lauren Spierer”